Anatomy and Physiology 12 Mutations Project
Background Information
Insulin is a protein that helps regulate the uptake of glucose from the bloodstream. However, some people have a point mutation in their DNA so that they can’t make insulin. This leads to the body being unable to uptake glucose, leading to a condition called diabetes. The inability to uptake glucose has many serious effects on the body. Your task is not to research diabetes or any other real disease caused by mutations, but rather to make up your own…….
Task
- Create a made-up protein
- Give it a name
- Give it a function[unique_solution]
| Emerging | Developing | Proficient | Extending |
| Protein is not made up.
Name does not make sense or relates to its function in the body.
The function is not a usual function of a protein | Somewhere in between | Protein is made up.
Name makes sense and relates to its function in the body.
The function is that of a protein |
- Explain how the protein is made
- Tell me its nucleotide sequence (make it 21 nucleotides long)
- Explain where the instructions are found
- Explain how it will go from DNA sequence to protein
- Tell me the mRNA sequence
- Tell me the tRNA sequences
- Tell me how many tRNAs will be used
- Include 5’ and 3’ on all nucleic acids!
- Tell me the amino acid sequence
- Explain how the amino acid chain will fold (review from biological molecules)
| Emerging | Developing | Proficient | Extending |
| More or less than 21 amino acids listed
No nucleic acids have the ends correctly labeled (5’ to 3’).
Steps for DNA to Protein are lacking accuracy, detail, molecules, and organelles
Folding not explained correctly or is lacking immense detail | Somewhere in between | Consists of 21 nucleotides.
All nucleic acids have the ends correctly labeled (5’ to 3’).
The steps for going from DNA to protein are correct, concise, detailed, and easy to follow. All the required molecules and organelles are listed, and their roles explained.
Folding of primary structure to tertiary or quaternary structure is clearly explained.
|
- Create a made-up mutation for your protein
- Explain what caused the mutation
- Explain what kind of mutation it is
- Explain where it happens in the nucleotide sequence
- Explain what happens to the amino acid sequence
- Explain hat the effects on the body are due to this mutation.
| Emerging | Developing | Proficient | Extending |
| Cause of mutation is an example of something that does not cause mutations
The type of mutation, its effects on the nucleotide sequence, amino acid sequence, and protein function is NOT explained
| Cause of mutation is an example of something that can actually cause mutations
The type of mutation, its effects on the nucleotide sequence, amino acid sequence, and protein function is explained |
Format is up to you. Write-up, poster, pamphlet, etc.
- Send it over TEAMS. MORE INFO ON THIS PART SOON as I am not sure the best way to submit assignments yet.
- Individually done
- No questions about what you are supposed to do.
- If I see any plagiarism, that is an automatic 0. There should be no overlap or similarities between you and anyone else in this class. There should also be no copy and paste from the internet as these are all MADE UP.
- Due Tuesday, April 21st, at 11:59 PM. There will be no activities for Thurs, Friday, Monday, Tuesday. Use that time to work on your project!