Association of Vitamin D Receptorgene polymorphisms with the occurrence of decreased bone density among participants with type 2 diabetes using classification and regression tree (CART) analysis Authors: Maryam Ghodsi[1] Abbas Ali Keshtkar [2] Shahin Roshani [3] Mahsa Mohammad Amoli [4] Ensieh Nasli-Esfahani 1 Bagher Larijani[5] Mohamad Reza Mohajeri 5 * *Corresponding Author, Email: mrmohajeri@sina.tums.ac.ir Conflict of interest Maryam Ghodsi, Abbas Ali Keshtkar, Shahin Roshani, Farideh Razi, Mahsa Mohammad Amoli, Ensieh Nasli-Esfahani, Bagher Larijani and, Mohamad Reza Mohajeri declare that they have no conflict of interest. Other authors Emails: Maryam Ghodsi: ghodsi@gmail.com, Abbas Ali Keshtkar: abkeshtkar@gmail.com, Shahin Roshani:roshani@ncdrc.info, Farideh Razi: razi@gmail.com, Mahsa Mohammad Amoli: amolimm@tums.ac.ir, Ensieh Nasli-Esfahani: nasli@yahoo.com, Bagher Larijani: emri@tums.ac.ir Keywords:CART analysis, Logistic Regression, cross-validation, VDR polymorphism, type 2 diabetes, osteoporosis. Title Summary We compared the accuracy performance estimation of in finding the association between five VDR gene polymorphisms and decreased bone density in people with type 2 diabetes (T2D) usingthe CARTanalyzing method. The results suggest that the ultimate model of the CART method has a highaccuracy performance estimation. Abstract Background:The osteoporosis research field is…
Optics According to Pedrotti et al. (2017), Optics is one of the branches of physics which deals with the study of the properties of light and its behavior when it interacts with objects. It mainly illustrates the character and behavior of ultraviolet, infrared and visible light. Optics comprises of two significant branches the geometrical and physical branches. The geometrical optics is mostly linked to the principles that govern the image-forming properties of mirrors, lenses and other devices which uses light. Physical branch major mainly with the original features and nature of light itself. Optics comprises optical data processing that involves the manipulation of the information content of an image formed by coherent optical systems. Previously optics was applied only in connection to the eye and vision after sometimes other devices and lenses aiding vision started to be developed, these were known as optical instruments, and the meaning of optics expanded to cover any application of light. During the 20th century, visual methods came to be applied more to areas of the electromagnetic radiation spectrum and not visible light to the…
Why The Great Outdoors Are Exactly What All Kids Need The outdoors provides a perfect opportunity for kids to be just kids and grow up in a normal way. All the jumping, rolling on the ground, tree climbing, and all sorts of games are great for kids. You will notice that kids that grew up in the countryside setups are happier and more active than those who are brought up in the cities. The outdoor experience is great for kids’ development, emotional control, and mental wellbeing. This article explains all the details you need to understand why the outdoors is great for kids. Mental Benefits The sounds, sunlight, smell, and games associated with the outdoor experience are important for the mental development of kids. The experiences of nature bring bout great restorative experiences. They help in stress recovery and mood development, which are all healthy for the brain. There is a lot of scientific development proving that kids who get enough outdoor experience become more focused and attentive hence likely to record good performances in school. Social Benefits When kids…
777 Casino’s players 777 Casino’s players get to enjoy a variety of offers and promotions. The new players specifically have several deposit bonuses and free spins that they can take advantage of. They include; Welcome Bonus Immediately after signing up with 777 Casino, you become eligible for the welcome bonus. This reward offers a 100% bonus on the initial deposit amount up to €200 on selected games. To get this reward, you have to make a minimum initial deposit of €20 and insert the coupon code ‘WELCOME777’ while making payment. To make a withdrawal of the bonus, you need to have wagered 30 times the bonus amount. 1st Deposit Bonus Apart from the welcome deposit bonus, new players can also take advantage of the first deposit bonus, which offers a 100% bonus of the initial amount up to €100. To get this reward, you have to enter the code 1LUCKY7 while making payment for the first deposit. 2nd – 5th Deposit Bonuses For the next deposits up to the fifth, a player earns a 30% bonus on the funding amount. To…
Genetic Engineering Example one Genetic engineering is the collection of technologies that influence organism. Genetic engineering is the technology that is used to change the genetic makeup of an organism. Gene is the basis of life. Gene is made-up of chromosomes: Y and X chromosome. Traits are normally passed from the parents to offspring through genetics (Morgan pg 7). Organisms produced through genetic engineering are known as; Modified Genetic Organisms (GMOs) There are various examples of genetic engineering. Firstly, the existence of fast-growing trees. The tall trees are crossed with small ones to produce those trees, which are resistant to adverse weather conditions. The offspring are accustomed to unfavorable conditions such as; the dry period. During the dry spell, those trees that are brought- up through genetic engineering are evergreen. Those trees are also resistant to diseases such as; Phytophthora and Anthracnose. Phytophthora interferes with the rooting system leading to falling of trees. On the other side, Anthracnose interferes with the leaf system hence the trees are not able to manufacture their food through photosynthesis. The common disease like…
Harley-Davidson, Inc.: Troubled Times Increase H-D′s Reliance on International Sales Read the Chapter Case, ″Harley-Davidson, Inc.: Troubled Times Increase H-D′s Reliance on International Sales,″ on pages 204-214, and answer the questions on page 214 in detail. The writing you submit must meet the requirements below. Summarize the case with at least two pages. Answer the questions on page 214 in detail. In answering the questions, kindly identify Michael Porter′s five forces and their management implications for multinationals. Format your summary and answers using APA style. Use your own words, and include citations and references as needed to avoid plagiarism. https://online.vitalsource.com/books/9781285696744/pageid/222[unique_solution] Harley-Davidson, Inc.: Troubled Times Increase H-D′s Reliance on International Sales Read the Chapter Case, ″Harley-Davidson, Inc.: Troubled Times Increase H-D′s Reliance on International Sales,″ on pages 204-214, and answer the questions on page 214 in detail. The writing you submit must meet the requirements below. Summarize the case with at least two pages. Answer the questions on page 214 in detail. In answering the questions, kindly identify Michael Porter′s five forces and their management implications for multinationals. Format your summary and…
EVIDENCE ANALYSIS The essay provided contains theoretical evidence which is lightly tackled without any substation facts to validate them. The essay takes about Kensal rise that is being closed but does not provide any reason for the cause and consequences. Instead, it concentrates of the option of friends of the library joining support to run the library. The paper talks about Willes Green being sacrificed due to opportunity for a lubricious deal but fails to describe the conditions that the allegations are true or not, this makes the content of the essay to be baseless. However, the essay tackles different types of libraries and claims that well-managed libraries are receiving a high volume of visitors while other is exactly the opposite. This is a good argument from the essay but does not include a few examples to affirm the reality. This makes the idea to lack meaning and what it speaks may not concur to the real-life situation. The essay blames the online library users to be the main cause of Kensal rise closure but does not mention any arguments…
Watch the video link below Watch the video link below. Answer the following 3 questions. Paper much be 1 1/2 pages double spaced in APA format 1:Describe onboarding. 2:What do you know now about your current position (or your last one) that you wish you had known before you accepted the position? If you had known this in advance, discuss how this would have impacted your decision to accept the position. 3:Assume you are a manager with a company that does a lot of hiring but does not have an onboarding program. Outline how you could convince the CEO of the company that the firm should invest in a comprehensive onboarding program. video link: https://hbr.org/2015/11/the-powerful-way-onboarding-can-encourage-authenticity Watch the video link below. Answer the following 3 questions. Paper much be 1 1/2 pages double spaced in APA format 1:Describe onboarding. 2:What do you know now about your current position (or your last one) that you wish you had known before you accepted the position? If you had known this in advance, discuss how this would have impacted your decision to accept the…
Forensic Science INSTRUCTIONS: The recent officer-involved fatal shooting of Antwon Rose in East Pittsburgh has gained national attention. In this case, the officer was charged by way of a general category of “criminal homicide” under Pennsylvania law. Let’s examine this case from a scientific and objective perspective and leave the emotional aspects, however legitimate, outside of this. Let′s suffice it to say that a tragedy did indeed occur, but how might forensic science be able to assist us in terms of gaining deeper knowledge in regard to: 1) The culpability of Rose, if at all, in regard to the initial drive-by shooting in North Braddock (and why this may or may not be relevant); and 2) The felonious conduct, if any, by the officer in regard to the shooting. [unique_solution]For this assignment, NOTES: **READ ABOUT THE SHOOTING. “East Pittsburgh Officer Michael Rosfeld charged in shooting death of unarmed teen Antwon Rose”. https://www.washingtonpost.com/news/post-nation/wp/2018/06/27/east-pittsburgh-police-officer-who-shot-and-killed-antwon-rose-charged-with-criminal-homicide/?noredirect＝on&utm_term＝.7ea0e29de973 You should include in your writings citations to newspapers including those that are online. Other citations should be to scholarly works as well as Pa. Cons. Stat. and relevant…
″Form″ VS. ″Function″ in Architecture ″Form″ VS. ″Function″ in Architecture: In your newly educated opinion, which is more important; and why? Writing in your own ″voice″, explain and support your stance on this debate. Use at least two-three relevant examples from the course content discussed, and integrate your newly developed architectural vocabulary to help support your responses. In other words, develop and present your ideas utilizing your new understanding of architecture you′ve gained from this course. (Warning: Only Use info you′ve learned directly from our course, such as the Powerpoint, videos or textbook -NOT info you randomly found online!)[unique_solution] ″Form″ VS. ″Function″ in Architecture: In your newly educated opinion, which is more important; and why? Writing in your own ″voice″, explain and support your stance on this debate. Use at least two-three relevant examples from the course content discussed, and integrate your newly developed architectural vocabulary to help support your responses. In other words, develop and present your ideas utilizing your new understanding of architecture you′ve gained from this course. (Warning: Only Use info you′ve learned directly from our course,…