Neurogenesis paper
SUMMARY
Neurogenesis is a broad and highly regulated process that ends in the production of other neurons. It occurs at high rates during the embryonic period when substantial quantities of new cells are generated and subsequently moved to the developing tissue.
The hypothalamus centrally regulates feeding behavior and energy balance. Nuclei that are found in the hypothalamus share interconnections and maintain the body homeostasis. The arcuate nucleus produces neuropeptides that act to increase food intake and others that act to reduce food intake. Neurogenesis is known to take place as the response of hypothalamic circuits and to the metabolic signals.
Hypothalamic feeding circuits in adult mice begin in the embryonic period and goes on for the initial weeks of postnatal life. In mice, some cells initiate the variance between the first postnatal days, a process that finalizes in the first month of life. The functions of Tanycyte are not clearly understood, but they have an involvement with the feeding behavior as the chemosensory cells and NPCs react to the diet alterations.
In the embryonic period, when the hypothalamic NPCs are coming to be, there are impacts upon the formation of enough NPC population. The proliferation of the hypothalamic NPCs in adult mice during the prenatal period is as a result of maternal diet manipulation and the availability of hormones. Young ones that are subjected to put a nutritional restriction in this period face a reduced NPC population with a decreased proliferation capacity. The result of this is a deficiency in body weight and feeding that comes along later. A maternal high-fat diet promotes the differentiation, proliferation in adult mice, increasing the density of neurons in newborns, which leads to a higher risk of obesity.