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pathophysiologic process, presenting signs, symptoms, and diagnostic abnormalities, and social determinants of health in hypertension

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pathophysiologic process, presenting signs, symptoms, and diagnostic abnormalities, and social determinants of health in hypertension

            Hypertension is a long run medical disorder whereby the blood pressure in the arteries is persistently elevated. In addition, it is the sustainable elevation of blood pressure in systemic arteries which will always result to increased morbidity and mortality in the long run. A patient with hypertension is articulated to have a systolic blood pressure that is beyond 140 mmHg or a diastolic blood pressure of more than 90 mmHg. It is the most dominant risk factor for cardiovascular illness and affects almost two-thirds of adults who are at least 60 years. It is anticipated that uncontrolled hypertension is accountable for millions of demise annually per year. The initial understanding of blood pressure can be traced in 1733 when Stephen Wales gauged intra-arterial pressure in a horse. It took nearly a century to develop sphygmomanometric devices that could measure blood pressure noninvasively, and these tools were launched into clinical practice in the late 1800s. Although the government has allocated significant budgets on medications and absent labour force, billions of individuals have continued to suffer due to the illness. Many randomized controlled trials have shown that even the slight blood pressure reduces including 10 mmHg decreases patients risks of death because of the cardiovascular illness and equivalent reduces the danger of stroke-related mortality, showcasing the necessity for novel therapies in the treatment of hypertension. The paper will discuss the pathophysiologic process, presenting signs, symptoms, and diagnostic abnormalities, and social determinants of health in hypertension.

Pathophysiologic Process

            Hypertension can be divided into secondary and primary forms. Primary hypertension represents 90% of the hypertension cases and poor diet and insufficient physical activity appear to be significant and potentially reversible environmental causes. A specific sometimes can be acknowledged in nearly 10% of adults suffering from hypertension, termed secondary hypertension. If the causes can be precisely diagnosed and treated, normalization of blood pressure or marked enhancement in blood pressure regulation with a concomitant decrease in cardiovascular risk (Carey & Whelton, 2018).

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Most of the patients with secondary hypertension have primary aldosteronism or renal vascular disease or renal parenchymal, while the rest might have more unusual endocrine conditions.

Pathophysiology is a branch of medicine that illuminates the function of the body as it is linked to illnesses and disorders. The pathophysiology of hypertension is an area which strives to illuminate mechanistically the causes of hypertension, which is a chronic illness that is linked with the elevation of pressure. The pathophysiology of hypertension entails the impairment of renal pressure natriuresis, the feedback system whereby high blood pressure invokes a rise in water and sodium excretion by the kidney that results to a decrease in blood pressure (Carey & Whelton, 2018). The pressure natriuresis can emanate from impaired renal function, suitable activation of hormones that control salt and water excretion by the kidney or extra activation of the sympathetic nervous system.

Hypertension is a chronic elevation of blood pressure that in the long run, causes end-organ damage and leads to increased morbidity and mortality. Blood pressure is the product of cardinal output and the resistance of the systemic vessels. It follows that patients suffering from arterial hypertension might have a rise in cardiac output, a rise in systemic vascular resistance or both. Among the young persons, the cardiac output is always elevated, whereas in older patients increased systemic vascular resistance and improved rigidity of the vasculature is instrumental. The vascular tone might be increased due to the rising a-adrenoceptor stimulation or increased emission of peptides, including endothelins and angiotensin. The ultimate pathway is a rise in cytosolic calcium in vascular smooth muscle triggering vasoconstriction (Carey & Whelton, 2018). Many growth factors, such as endothelins and angiotensin, lead to a rise in vascular smooth muscle regarded as vascular remodelling. An increase in systemic vascular resistance, as well as vascular stiffness, improves the load imposed on the left ventricle, and this invokes left ventricular hypertrophy and diastolic dysfunction.

The pulse pressure produced by the left ventricle is comparatively low, and the waves reflected by the peripheral vasculature happen after the end of systole thereby increasing pressure during the preliminary stages of diastole and enhancing the coronary perfusion (Stephen et al., 2019). As an individual grows older, the stiffening of the aorta and elastic arteries improves the pulse pressure. The reflected wave tends to shift from the early to the late systole. This leads to an increase in left ventricular afterload and leads to the left ventricular hypertrophy. The widening of the pulse pressure with ageing is a strong determinant of coronary heart illness.

The autonomic nervous is instrumental in the regulation of blood pressure (Carey & Whelton, 2018). In hypertensive patients, both release and improved peripheral sensitivity to norepinephrine can be discovered. Additionally, there is an improved responsiveness to stressful stimuli. Another characteristic of arterial hypertension is a resetting of the baroreflexes and reduced sensitivity of the baroreceptor. The renin-angiotensin system engages in some kinds of hypertension and is repressed in suppressed in the availability of primary hyperaldosteronism (Stephen et al., 2019). The elderly or black patients appear to suffer from low-renin hypertension. Others have high-renin hypertension, and these are more probable to develop myocardial infarction and complications.

Volume regulation and the association between blood pressure and the exercise of sodium are abnormal in human essential and experimental hypertension. Considerable evidence shows that resetting of pressure natriuresis is instrumental in causing hypertension. The resetting of pressure natriuresis is defined by a parallel shift to higher blood pressure and salt-cautious hypertension or a reduced slope of pressure natriuresis and salt-sensitive hypertension (Stephen et al., 2019).

Dysfunction in any of these processes can result to hypertension development. This might be through rising cardiac output, improved systemic vascular resistance or both. Blood vessels become less elastic and more rigid as a parent grow older, which decreases vasodilation and improves systemic vascular resistance resulting in higher systolic blood pressure (Stephen et al., 2019). On the contrary, hypertension in younger parents tends to be linked with an increased cardiac output which can be caused by genetic aspects.

 Presenting Signs, Symptoms, and Diagnostic Abnormalities

Hypertension is regarded as a silent killer because it does not produce any symptoms in individuals. The doctors use blood pressure to diagnose a patient suffering from hypertension. Most persons suffering from hypertension are not knowledgeable that it is a crucial risk factor for heart attacks.  The symptoms of hypertension might be present in those who have very high blood pressure.

Symptoms that do happen, if present, might show temporary elevations in blood pressure, and can be linked to the timing of doses. The symptoms of hypertension might occur at any moment and do not last for long. First, one of the presenting signs and symptoms of hypertension is recurrent headaches. Notably, headaches are common among persons suffering from hypertension. Some individuals with hypertension notice deteriorating of headaches when medications are skipped or when the blood pressure rises than normal. Headaches linked with hypertension can be severe, moderate, or mild and can have a throbbing nature. Second, dizziness highlights another sign of hypertension. Individuals suffering from hypertension might notice that dizziness is linked with doses and fluctuation of blood pressure. Third, the shortness of breath presents a sign and symptom of hypertension. Hypertension can cause shortness of breath because of the impact of the lung and heart function (Stephen et al., 2019). It is vital to understand that shortness of breath is more observed with engaging in physical exercises. Fourth, nosebleed among individuals highlights a sign and symptom of hypertension. Sometimes people nosebleed even when they do not suffer from hypertension. Fifth, individuals suffering from hypertension face difficult with vision (Spikes et al., 2019). These persons have blurred vision and changes in vision which act as a warning about the risk of a stroke or heart attack. Sixth, individuals suffering from hypertension vomit many times, have nausea and lose appetite. Nausea linked with severe hypertension can develop promptly and might be associated with dizziness.

Diagnosis of abnormalities highlights the existence of hypertensive retinopathy which illuminates that persistent, untreated high blood pressure can cause damage to the retina. Here, the tissues at the back are accountable for receiving the images that an individual requires to see. Hypertensive retinopathy happens when the blood vessels supplying blood to the retina in the back gets damaged. The probability of damage to the retina rises with the severity of high blood pressure and the duration in which the disorder is experienced.

Current Research

The research on the pathophysiological determinants of blood pressure fascinates me. Primary hypertension emanates from the integration of genetic and environmental aspects. The heritability of blood pressure is between 30% and 50%, reflecting the degree of phenotypic resemblance among family kin, and relies on the shared genetic background leading to blood pressure and environmental aspects and their interactions with the genome (Carey et al., 2018).

It is clarified that the main determinants of blood pressure in primary hypertension and their interactions in adults. Environmental factors, including unhealthy diet, intake of sodium, potassium intake, obesity, and physical inactivity, lead to hypertension. The genetic aspects such as gene-gene interactions, fetal programming, epigenetic mechanisms, and many risk alleles each will tiny defects cause hypertension in adults (Carey et al., 2018).

Role of Social Determinants in Hypertension

The social determinants of health are situations whereby individuals are born, live, grow, work, and age and the systems to handle the illness (Carey et al., 2018). This statement constitutes the view that health and disease are not distributed randomly throughout humans, and neither are resources to impede hypertension and its side effects. Instead, they cluster at the intersections of economic, social, interpersonal, and environmental forces. The examples of the social determinants of health are access to medical care, culture, education, race and ethnicity, education, wealth and income, employment, and residential environments.

Social status epitomizes the social defined economic aspects that impact the positions or groups or in the stratified structure of a society. Even though social determinants are often invoked in discussions of disparities, social aspects impact cardiovascular health in each person. In the United States, a strong link coexists between social determinants of health and hypertension, particularly in minority populations (Carey et al., 2018). Hypertension is more dominant in blacks and whites, and the former raises the risks of stroke and kidney disease disproportionately in blacks. Also, blacks are more probable to have unregulated hypertension significantly because of lower blood pressure control rates, whereas taking anti antihypertensive medication.

Neighbourhood features might impact the prevalence of hypertension. Persons residing in economically deprived neighbourhoods have higher likelihoods of having high blood pressure. A link exists between the residence in particular geographical areas and the prevalence of hypertension (Carey et al., 2018). Social determinants are vital to the prevention and control of hypertension in the population.

Education

High levels of educational attainment are linked with a lower prevalence of hypertension risk factors, lower hypertension mortality, and frequency of hypertension, independent of sociodemographic factors. Both low health literacy and numeracy might intervene in the association between higher education and hypertension, with low health literacy linked with having less than a high school education and poor health results.

Educational attainment is linked with better options for income and employment, which can impact the health-seeking norms and access to healthcare (Carey et al., 2018). Having less education and a poorly-paying job is linked with less social supports-the networks and behaviours that support health norms and discourage health-damaging practices.

As adolescent spent the majority of their waking hours in academic institutions, learning settings have an exceptional opportunity to promote health in their curricula and through the social environment. A school curriculum agitates for health through wellness courses, sex education, and physical education (Carey et al., 2018). Physical education courses integrated with nutritious school lunches have been discovered to mitigate childhood obesity in the short run and might impede children from being a long overweight run. A regulatory and social environment of an academic institution can impact hypertension, including smoke-free settings and the establishment of social behaviours.

Availability of resources to meet daily needs

The safety of the residential environment can have an impact on the capability of both exercises and eat a balanced diet. Individuals who feel unsafe where they reside might be more probable to stay at home, leading to less physical activity (Carey et al., 2018). The feeling of being unsafe might trigger more stress as well as stress-associated hormones. These stress hormones might promote the gain of weight. There is a definite data that supports a link between that perception of safety and health markers such as weight and even blood pressure.

Wealth and Income

            Income is closely linked to health. Notably, income and wealth offer access to better situations such as health-producing circumstances including safe places to reside or access to healthier foods (Carey et al., 2018). Having lower household income impacts the degree at which individuals can afford to make such health-promoting options for themselves, their families, and communities.

Residential segregation

Segregation has repetitively to be linked with worse health results for minority residents because of limited funding in these communities in less access to health-producing products and services and greater rates of crime and violence (Spikes et al., 2019). The members of segregated communities have greater infant mortality rates, shorter life expectancies, and poorer mental health (Himmelfarb et al., 2016).

Race and ethnicity

People have no self-control over their race and ethnicity. Even though an unfortunate reality, individuals do encounter distinct health outcomes and health norms relying on their race, and African Americans are always the social groups burdened with worse health outcomes (Himmelfarb et al., 2016). The poor health results of certain racial groups are linked with other social determinants that disproportionately affect them such as the low socioeconomic status, segregation in neighbourhoods, and prejudice in the workstation (Spikes et al., 2019).

Living environment

Living environment stretches beyond nursing to the regulatory, economic, social, and physical environment of a community. Whereas an individual impacts the access to health-promoting products and services such as nutritious food choices, medical care services, and fitness centres appropriate for exercising. Elements including walkable neighbourhoods, recreational space, and public transportation choices, and recreational spaces such as playgrounds (Carey et al., 2018). The rising public transportation in a community has been demonstrated to reduce the number of missed or delayed medical visits leading to better health results and lower rates of hypertension.

Conclusion

Hypertension is one of the most prevalent chronic illnesses globally. However, most individuals have hypertension without awareness and treatment of the illness, showing it is essential to offer some fundamental knowledge and essential information of hypertension to the audience at the early phase of the life to prepare for prevention of hypertension. Also, the pathophysiology of hypertension is a region which aims at explaining mechanically the causes of hypertension, which is a chronic disorder that is associated with an increase in pressure. Hypertension is regarded as a silent killer because it does not generate any symptoms in individuals. The social determinants of health are circumstances whereby persons are born, live, work, grow, and age and the systems to deal with the disease process.  Enhancing health outcomes globally will necessitate concerted global deeds to address the burden of hypertension. The future of hypertension requires transformation. Its future will rely on the successful convergence of digital data and biotechnological sciences integrated with their implementation in delivering healthcare with new models of delivery and the effective approach of population health.

 References

Carey, R. M., & Whelton, P. K. (2018). Prevention, detection, evaluation, and management of high blood pressure in adults: synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline. Annals of internal medicine, 168(5), 351-358.

Carey, R. M., Muntner, P., Bosworth, H. B., & Whelton, P. K. (2018). Reprint of: Prevention and control of hypertension: JACC Health Promotion Series. Journal of the American College of Cardiology, 72(23), 2996-3011.

Himmelfarb, C. R. D., Commodore-Mensah, Y., & Hill, M. N. (2016). Expanding the role of nurses to improve hypertension care and control globally. Annals of Global health, 82(2), 243-253.

Spikes, T., Higgins, M., Lewis, T., & Dunbar, S. B. (2019). The associations among illness perceptions, resilient coping, and medication adherence in young adult hypertensive black women. The Journal of Clinical Hypertension, 21(11), 1695-1704.

Stephen, C., Halcomb, E., McInnes, S., Batterham, M., & Zwar, N. (2019). Improving blood pressure control in primary care: The ImPress study. International journal of nursing studies, 95, 28-33.

 

 

 

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