toxicities are horrible
If you let floral yours still built up in the cell, we’re toxicities are horrible. Gi do, we don’t do terpene yet, right on most of our cancer into WIP,retinal nuclear interference, serious myelin oppression, GI distress, stomatitis, bloody diarrhoea, and central toxicity that can go from some cognitive dysfunction who encephalopathy thing called cerebellar syndrome and unrelenting theme. So this is not a drug you want to have accumulated. So people who are the blogger dot hydro permitting dehydrogenase is polymorphic in about 5 percent of population don’t make it or make very small quantity than they are at risk.If you get standard doses of glory yourself, they are at risk for this toxicity because you’re not going 85 percent of that dose of four year shows that depending on that enzyme to be inactivated. And if you don’t have that, enzyme levels are kind of go up. And I talked about the nice group chat with her about what chemistry when I get a excited about find out from a clinical perspective how this played out in the firm, and she said It’s about 60 per patients present with four-year fill toxicity has enhanced responsible it yourself. About 60 percent of them will be Core. We can eat metabolite cathedrals. So when I put a paper on their website for if you wanted to talk about it in black. And the young panned out, but there was a, forgot the name of the group that they devise the bedside way of looking at uracil versus dihedral Europe. You’ll take a blood sample from a patient right then and there and doing a ratio on how much urine still is reduced to dihydrogen . And based on how effective that was, determining whether that patient was likely a poor BBB metabolizer. And if they were, I think for ratio, but we worked with them for the ratio of dihydrogen of teeth on your hill that was greater than four. They comfortable according to some guidelines to keep that person saying if you’ve kept the, cut the dose back to keep those levels from growing up. So you don’t have to necessarily want you the cheek swab and send it out. They’ve got this little bedside Wade, who predict which patients are going to be over responders to this and cut to those back. Don’t wear them, get toxic do it dropped off. Keeping these goals really cool. Little bed file that anybody can do. Anybody can do that. It has a lab available to lie. So set that up was pretty cool. So now which one of our, our you’re still analog, but we have to worry about that? You are given three different patients. One von Fourier Which page has Would you want to be doing that little bedside tests on to know whether you could decrease the dope. Any rug on one of these but generates, plural, uracil is at risk for that. Well, obviously poor Europe whole generates what it inflow Europe. So, right. So a five that view is your drug. You want to be sure, you know, is that patients are core DPV metabolizer law. And if they are, what are you going to do? Harp that.