high dosage treatment inefficiencies
Sobel et al. (2019) argued that the high dosage treatment inefficiencies were caused by the application approach of the drugs, especially through oral. Sobel et al. (2019) found that the high dosage treatments had to go through the digestive systems and ascend into the infected vaginal area, and this reduced its efficiency and strength in combating bacterial vaginosis. Sobel et al. (2019) also showcased that this caused the various bacteria causing the bacterial vaginosis to survive and later regenerate, leading to a second reoccurrence. As such, Sobel et al. (2019) found that increasing the intensity of the metronidazole drug was an inadequate approach as its efficiency decreased as the medication traveled through the body’s various systems before reaching the target area. For the Vitamin D high dosage treatments, McClelland et al. (2015) found it had zero effect as vitamin D application did not correlate bacterial vaginosis. Hence, McClelland et al. (2015) showed that it was inapplicable for women of reproductive age suffering from bacterial vaginosis.
Heczko et al. (2015) analysis of the direct application of metronidazole to the affected area, vaginal region, had a higher success at curing bacterial vaginosis and preventing its reoccurrence. Heczko et al. (2015) showcased Sobel et al. (2019) concerns of oral metronidazole of being inefficient due to the pathway the medication had to travel to reach the infected vaginal region. However, Heczko et al. (2015) found that the use of metronidazole vaginal gel to the vaginal region was more efficient. Heczko et al. (2015) found that adding Myrtus (Myrtus communis) extract with the drug increased the effectiveness of the method in preventing the reoccurrence of bacterial vaginosis.
Hakimi et al. (2018) also agreed with Heczko et al. (2015) and found that the direct application of metronidazole to the vaginal area increased the efficiency of the drug efficiency. Same as Heczko et al. (2015), Hakimi et al. (2018) found that using metronidazole gel with prebiotic vaginal gel increased the curing and prevention of reoccurrence by 76%. As such, there is a need to promote the use of direct application of drugs used to treat and prevent the reoccurrence of bacterial vaginosis.