Cymanquine – A New Organometallic Anticancer Agent Experimental Procedures Syntheses of Cymanquine     A dried round bottomed flask was charged with dry cymantrene (0.20 g, 1.0 mmol) dissolved in THF (2.5 mL) was reacted with n-BuLi (0.55 mL,1.20 mmol) at -50°C. After 1 hour, the solution was cooled down to -78°C and DMF (0.15 mL, 1.5 mmol) was added to the reaction mixture which was left at -78°C for 1h before warms it up slowly to room temperature for 2 hours. Hydrolysis was performed by addition of a satured solution of NH4Cl solution. The aqueous layers were extracted twice with Diethyl Ether and the combined organic layers were washed with water, dried over Na2SO4, concentrated under vacuo. Formylcymantrene was obtain as a yellow oil (93 %). The product is engaged directly in the next step without further purification. The product is degradable after 1-2 days without the following precautions: Keep away from light and keep on the freezer.   1H NMR (500 MHz, DMSO-d6) δH 9.62 (s, 1H), 5.82 – 5.80 (t, J= 2.3 Hz, 2H), 5.28 (t, J…

DISRUPTIVE TECHNOLOGIES All sources must be properly cited and no more than 20% should be direct quotations from other sources. In other words, you may not copy/paste/cite your way to a 6 – 8 page paper. Length: The paper should be 6 (1700+ words) to 8 (2250+ words) double spaced pages not including cover pages or reference pages. Follow the American Psychological Association (APA) style. There should be a minimum of 4 references, preferably from peer-reviewed academic journals, which you can access through the UTPB Library databases, EBSCO, Business Source Complete, or reputable news sources or company websites. [unique_solution]Topics: The paper topic may be on any of the topics covered in the assigned readings or any topic directly related to the topics in this course, such as application in a particular industry. Grading Rubric: In the Individual Paper assignment 80 points are awarded based on the appropriateness of the topic to the course and quality of sources and quality of the content. There will be a major point deduction for excessive use of quotations to fill the paper by copy/paste/cite…

The Epic of the Cid  Assignment: Write a paper (1300-1500 words) with a thesis statement and argument backed up with evidence from the primary source you have just finished reading, The Epic of the Cid. Your paper will be a response to one of the questions provided, with your answer serving as your thesis statement. In this text, the Cid is an ideal knight. What makes him an ideal knight? Focus on one very specific aspect and draw on evidence from throughout the text to support your conclusion. You might consider him as a warrior, as a lord or a vassal, or as a father and husband. The Cid is set in the time of the Reconquest and is a warrior. Was he fighting for religion? If not, what was he fighting for? identify one focused answer and support with evidence from throughout the text. [unique_solution]Citing Evidence: It is important for you to ground your argument in evidence from both primary sources. Incorporate the source material into your own writing by paraphrasing or quoting. Because your references should be confined…

Isolation, Protein Analysis and Subcellular Fractionation of Mitochondria Introduction Several paragraphs describing the background to the different parts of the experiment and how they support the main focus of the experiment (subcellular fractionation of mitochondria by centrifugation, why use SDH etc?).   Aim The aim of the experiment is to isolate mitochondria from toad liver, analyze subcellular fractionation of mitochondria by centrifugation and analyze protein using BCA assay.   Methods The toad liver was prepared by technical staff. The whole cell lysate (WCL) was pelleted and the supernatant was obtained and placed in the MITO (mitochondrial fraction) tube. Next it was centrifuged three times to obtain three supernatant solutions labelled SN1, SN2 and SN3. Isolation-buffer was used to resuspend the pellet and to isolate subcellular fractions from the cell lysate by differential centrifugation. Next a BCA assay was used to determine the protein concentration of the SN1, SN2, SN3, WCL and MITO tubes using absorbance of 595nm and a BCA standard curve was obtained. Mitochondria was isolated by testing for the presence of succinate dehydrogenase activity. It analyzed subcellular fractions…

Position paper on Religious Freedom Position paper on Religious Freedom Describe the issue in detail, including background information and major arguments of ALL sides. Then, indicate your position. Support your argument with facts and figures. Into paragraph-issue background and details Then include major arguments-pro. Then include major arguments-con. Then your position. Conclusion Not a limit on cited sources but need to use MLA and parenthetically cite the sources throughout the paper and list the sources in a Works Cited at end of paper. So the paper would be 7 pages and the Works Cited would make it 8 pages.[unique_solution] Position paper on Religious Freedom Describe the issue in detail, including background information and major arguments of ALL sides. Then, indicate your position. Support your argument with facts and figures. Into paragraph-issue background and details Then include major arguments-pro. Then include major arguments-con. Then your position. Conclusion Not a limit on cited sources but need to use MLA and parenthetically cite the sources throughout the paper and list the sources in a Works Cited at end of paper. So the paper…

Preparing definition essay Prepare a definition essay establishing the legitimate status of one, specific subculture (to which you do NOT belong). Your final essay should be 1,000 words, typed and formatted according to MLA guidelines. You may only use three sources (“What is Culture” and two personal interviews). In your definition essay, you will argue that the specific subculture you have chosen has all the criteria for culture as defined by Richard Pearce in our reading. Your subculture will have its own specific institutions and conventions that are perpetuated through its own means of socialization and coercion. To begin, you’ll need to select a subculture to which you do NOT belong, but which you can access via interview. You’ll need to find three people you can interview, but you’ll only need to cite two of the interviews in your essay. Subcultures are based around a common ground that can either be classically cultural (an ethnic group), spiritual (less common religious groups like Wiccans), occupational (skydive instructors or computer hackers), or interest based (nudists, gamers, and renaissance fairgoers). [unique_solution]Wikipedia will give…

Prepare a 10-minute presentation Prepare a 10-minute presentation (10-15 slides, not including title or reference slide) on organizational culture and values. 1.Describe how alignment between the values of an organization and the values of the nurse impact nurse engagement and patient outcomes. 2.Discuss how an individual can use effective communication techniques to overcome workplace challenges, encourage collaboration across groups, and promote effective problem solving. 3.Identify a specific instance from your own professional experience in which the values of the organization and the values of the individual nurses did or did not align. Describe the impact this had on nurse engagement and patient outcomes. While APA style format is not required for the body of this assignment, solid academic writing is expected and in-text citations and references should be presented using APA documentation guidelines, which can be found in the APA Style Guide, located in the Student Success Center. [unique_solution]This assignment uses a grading rubric. Instructors will be using the rubric to grade the assignment; therefore, students should review the rubric prior to beginning the assignment to become familiar with the…

Cell Preclinical Trials The concept of stem cell discovery from animal preclinical trials to human subjects comes in handy in making new developments in the health sector. However, such trials should follow several steps as per the FDA guidelines that work to ensure that such tests do not pose unprecedented side effect to human beings. The FDA offers guidelines on how to undergo the entire process towards ensuring the process is transparent in all dimensions of practice and the event, ensure confidence to practitioners and the general public. The stipulated guidelines provide a level playing ground for all stakeholders and ensure the research follows a framework that sets standards for the industry. Steps in the preclinical trials The initial test should be carried on healthy volunteers towards establishing any side effects that may be associated with the stem cell discovery. The ideal number of the trial subjects should range between 20 to 80 people. The first step is essential in ensuring the safety of such tests on humans and avoid risking the entire process by exposing the trials to a…

Progesterone Progesterone is a category of prescriptions referred to as progestins, usually composed of female hormones. Further, the progestin hormones operate as a section of hormone replacement treatment by minimizing the quantity of estrogen within the uterus. Also, it functions to enhance menstruation periods amidst child-bearing females through replacement of the natural progesterone that various females may lack. Notably, lack of natural progesterone in females results in incidents of missing menstruation period. Additionally, progesterone prescriptions are employed as a segment of hormone replacement treatment in females who are past menopause stage and have not undergone hysterectomy (a surgical operation to eradicate the uterus). Subsequently, the hormone replacement treatment incorporates estrogen, which is core for the therapy of various symptoms of menopause and minimization of the perils of developing various illnesses. Nevertheless, the estrogen may lead to abnormal thickening of the relevant patient uterus wall and elevate the hazard of growth of uterine cancer. Therefore, progesterone aids to avert the thickening and thus limiting the threat of uterine cancer development On the other hand, abnormal uterine bleeding refers to any heavy…

Migrant Workers in China Social justice issues embrace the aspect of people receiving sanctions based on the nature and ways of action performance. Nonetheless, social justice stands for the idea that all people not only just deserve but also should have access to the same resources and rights. Unemployment, poverty, drug abuse, sexual abuse, and economic deprivation form the major social problems that are associated with the justice systems of most countries on the planet.  One can support social justice movements in their countries and communities through educating themselves based on social justice and its importance, working in own beliefs and habit and taking effective and just actions in the community. Centering my argument on the migrant workers in China, they are being faced with a series of issues. By 2017, over 277 million migrant’s workers were existing in China (CITE). From a social perspective, migrant workers in China do not have equal rights in having same job opportunities, in having similar wages, in providing education for their children in urban cities, and in obtaining healthcare services as urban citizens.…