Microchimerism

Microchimerism

            These are small number of cells that come from another individual and are hence different from those of host individual. The cell may be transferred from mother to child during birth; mother cells may persist in the offspring after birth or even the fetus cells persisting in the mothers.

How microchimeric cells escape the surveillance of the immune system

The microchimeric cells will attack the body and tend to defeat its immune system from destroying them. There are various means and ways through which these cells will be able to tolerate the body immune system. Some of the ways are as follows; For instance the available white blood cells whose work is to fight diseases and those foreign cells may also be foreign hence they tend to be inefficient to function well. The other cause of this is because the gestation periods weaken the immune system of the mother making her body immune system unable to function well. This will make her unable to kick away those cells. The other instance which may result to the cells tolerating the immune system is the lack of mature lymph nodes restraining homeostatic activation in the body of the foetus. This will make the foetus unable to fight these foreign cells hence their multiplication in the entire body.

Proposed role of cells in autoimmune disease

Some of the cells such as the B cells and dendritic cells have various functions when it comes to autoimmune diseases. Some of these functions are as follows. The cells may help in secretion of antibodies which help in fighting of diseases. In some cases the antibodies have a pathogenic effect. Other functions of these cells include;

• assisting in the secretion of inflammatory cytokines of the body
• control of antigen processing and presentation
• generation of ectopic GCs
• presenting of auto antigen in the body

Example of autoimmune diseases

There are very many autoimmune diseases. One of these diseases includes the type 1 diabetes. Type 1 diabetes may be characterised by the following signs and symptoms;

• Bedwetting in children who previously didn’t wet the bed during the night.
• Blurred vision
• Extreme hunger.
• Fatigue and weakness.
• Frequent urination.
• females, a vaginal yeast infection
• Increased thirst.
• Irritability and other mood changes.
• Unintended weight loss.

The disease affects many body organs including heart, kidney and the nerves among others. Its complications may be long term and to some extend tend to be life threatening.

Hashimoto disease is the disease which leads to an underactive thyroid gland. It may be characterised by;

• Cold intolerance
• Constipation or fewer than three bowel movements a week
• Depression
• Dry, thinning hair
• fatigue
• Joint and muscle pain

Despite some of these diseases resulting from pregnancy physicians should actually encourage pregnancy. This is so because this is only the best way of procreation as compared to the other artificial methods such use of crowning methods. This is because some of the artificial methods may be accompanied by some complications and at the same time being expensive to implement.